Long-Term Effects of Clofibrate (Atromid-S)
نویسنده
چکیده
Clofibrate was administered to 45 patients for varying periods of time up to 4 years with no evidence of chronic toxicity. Clofibrate was more effective in lowering serum triglycerides than serum cholesterol, with more than 75% of all patients with elevated triglycerides having at least a 25% reduction in triglycerides, the absolute reduction in triglycerides being directly correlated with pretreatment values. A reduction in serum cholesterol of 15% or more was obtained in 50% of all patients, those individuals with elevations of triglycerides having the greatest reduction in serum cholesterol as well as being most likely to respond.
منابع مشابه
Effects of clofibrate with androsterone (atromid) and without androsterone (atromid-S) on blood platelets and lipids in ischaemic heart disease.
A mixture of androsterone and clofibrate (atromid) lowers the blood cholesterol and triglycerides (Oliver, 1962). Clofibrate without androsterone (atromid-S) appears to have the same effect on the serum lipids (Oliver, 1963; Hellman et al., 1963). Atromid lowers platelet stickiness (Carson et al., 1963a, b) which is increased in patients with ischamic heart disease (McDonald and Edgill, 1957); ...
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In the early studies on atromid, which is ethyl p-chlorophenoxyisobutyric acid (clofibrate or C.P.I.B.) with androsterone, Thorp (1962) reported that, in monkeys, this preparation increased uric acid excretion in addition to lowering plasma lipids. Also Oliver (1962) reported that atromid lowered serum uric acid levels in patients with ischaemic heart disease. We therefore investigated its poss...
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References GREEN, K.C. & MARGARETZ, G. (1967) Long-term follow-up of multicentre trial of ethyl-a-p-chlorphenoxyisobutyrate (Clofibrate, 'Atromnid'-S) and Clofibrate Plus Androsterone ('Atromid'). Progress in Biochemical Pharmacology, 2, 378. KATSILAMBROS, BRAATEN, J.B., FERGUSON, D. & BRADLEY, R.F. (1972) Muscular syndrome after clofibrate. New England Journal of Medicine, 286, 1 10. LANGER, T...
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CHANGES in the levels of the blood lipids during attacks of acute closed-angle glaucoma were studied by Hanisch, Blumenfeld, and Hegeduis (1966), who found that there was a rise in the concentration of.the non-esterified fatty acids during the attack. Accordingly Orbain, Hanisch, and Vereb (1966) treated this condition with a single dose of 15 g. Atromid-S (clofibrate) and claimed that the atta...
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Platelet function was evaluated in 29 patients with familial hyperbetalipoproteinemia; 17 were untreated and 12 were receiving clofibrate (Atromid-S). In comparison with 26 normal subjects, the untreated patients aggregated in response to 1/3 the concentration of adenosine diphosphate (ADP), '/25 the concentration of epinephrine, and '/4 the concentration of collagen. Treatment with clofibrate,...
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